HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 8-Fluoro-4-[2-(4-methylphenyl)ethoxy]quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Methylphenethyl alcohol | HCID 95294 | — |
| Reactant | 4-Chloro-8-fluoroquinazoline | HCID 19939133 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-Fluoro-4-[2-(4-methylphenyl)ethoxy]quinazoline | HCID 19939085 | — |
Reaction Steps
To a mixture of 0.6 g of sodium hydride (50%, suspension in oil) and 2 g of 4-chloro-8-fluoroquinazoline in 20 ml of DMF was added 1.64 g of 2-(4-methylphenyl)ethanol, and the mixture was stirred for one hour. Then the mixture was poured into ice water. The solid was collected by filtration. Yield: 0.7 g (20.5%). M.P. 72°-74° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05411963 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-25910daf5c584d5dabadded8b8a7a749 |
| Source note | uspto-grants-1995_05 |