1,1-Diethyl-3-[13-(1,3-dithiolan-2-yl)-2,6-dimethyl-8alphaergolinyl]-urea → 1,1-Diethyl-3-(2,6,13-trimethyl-8alpha-ergolinyl)-urea

Participants

Reaction Steps

458 mg of 1,1-diethyl-3-[13-(1,3-dithiolan-2-yl)-2,6- dimethyl-8alpha-ergolinyl)-urea (1 mmol) is dissolved in 50 ml of methanol and treated with several portions of Raney nickel at room temperature until the initial material has disappeared according to thin-layer chromatography. It is filtered by kieselguhr, the solvent is concentrated by evaporation and the residue is chromatographed on silica gel with dichloromethane/methanol, the isolated substance is crystallized from methanol, yield 117 mg (31% of theory).

Provenance & Evidence