Pyridine, 2-methyl-4-nitro-, 1-oxide → HCID 178428516, compound
Reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][N+:3]=1[O-:11]>CO.[Pd].C>[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N+:3]=1[O-:11]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
4 g of 2-methyl-4-nitropyridine-N-oxide were dissolved in 90 ml of methanol and reduced with 1.2 g of 10% Pd/charcoal and H2. The catalyst was filtered off and the filtrate rotated in. The residue was boiled with 200 ml of ethyl acetate, filtered hot and the filtrate was mixed with 100 ml of hexane. The crystals precipitated after cooling the solution was sucked off, washed and dried. 3.1 g of 2-methyl-4-aminopyridine-N-oxide were obtained.
Workup
- filtrationThe catalyst was filtered off
- filtrationfiltered hot
- additionthe filtrate was mixed with 100 ml of hexane
- customThe crystals precipitated
- temperatureafter cooling the solution
- washwashed
- customdried
Sources & evidence
- ORD record
- ord-89149ce471274d54bb86c6416d849b1f
- Source dataset
- uspto-grants-1991_03
- Patent number
- US04997835
Reaction notes
Loading…