1,6-Dibromohexane → 1-[2-[(6-Bromohexyl)oxy]ethyl]naphthalene
Reaction equation
[C:1]1([CH2:11][CH2:12][OH:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]Br>>[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:13][CH2:12][CH2:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1Participants
3
Procedure
1-Naphthaleneethanol (3.00 g) and 1,6-dibromohexane (12.73 g) were treated according to the method of Intermediate 1. FCC eluting with cyclohexane followed by ethyl acetate-cyclohexane (1:20, then 1:4) gave the title compound (4.32 g) as a colourless oil.
Workup
- washFCC eluting with cyclohexane
Sources & evidence
- ORD record
- ord-e2883fd4c9084e1baf143fc31f88a3df
- Source dataset
- uspto-grants-1991_03
- Patent number
- US04997986
Reaction notes
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