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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 35945Generated: October 26, 2026

Acetone Cyanohydrin → 2-((4-Hydroxybutyl)amino)-2-methylpropanenitrile

https://huagongshe.com/reaction/35945

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetone CyanohydrinHCID 6406—
Reactant4-Amino-1-butanolHCID 25868—
SolventDichloromethaneHCID 6344—
Product2-((4-Hydroxybutyl)amino)-2-methylpropanenitrileHCID 15511961—

Reaction Conditions

Temperature20 °C

Reaction Steps

220 μl of acetone cyanohydrin and 200 μl of 4-amino 1-butanol were mixed together with stirring for 16 hours at 20° C. and then was diluted with 2 ml of methylene chloride, dried, filtered and the filtrate was concentrated under reduced pressure to obtain the propanonitrile which was used as is for the following stage.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05411981
Source datasetuspto-grants-1995_05
ORD IDord-af507ea0ea16417b8b65e6f6abd9ae52
Source noteuspto-grants-1995_05