Imidazole → 1-[[3-[[3-(Hexadecyloxy)-2-methoxypropoxy]methyl]phenyl]methyl]-1H-imidazol

HRID 35953

Reaction equation

Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][O:10][CH2:11][CH:12]([O:31][CH3:32])[CH2:13][O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH:4]=1.[NH:33]1[CH:37]=[CH:36][N:35]=[CH:34]1>C1(C)C=CC=CC=1>[CH2:15]([O:14][CH2:13][CH:12]([O:31][CH3:32])[CH2:11][O:10][CH2:9][C:5]1[CH:4]=[C:3]([CH2:2][N:33]2[CH:37]=[CH:36][N:35]=[CH:34]2)[CH:8]=[CH:7][CH:6]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]

Participants

Conditions

Temperature: 80 °C

Procedure

a mixture of 2.4 g of 1-(bromomethyl)-3-[[3-(hexadecyloxy)-2-methoxypropoxy]methyl]benzene, 2.54 g of imidazole and 30 ml of toluene was heated at 80° C. under argon in a pressure bottle for 4 hours and then evaporated. The residue was purified by chromatography, giving 2.02 g of the desired product as a colorless oil.

Workup

customevaporated
customThe residue was purified by chromatography

Sources & evidence

ORD record: ord-786f211439ef46fe9014490b5ebd34f7
Source dataset: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05411983

Linked notes

Loading…