Phosphorus sulfide (P2S5) → HCID 20064187, compound
Reaction equation
[O:1]=[C:2]1[NH:6][C:5]([CH3:7])=[C:4]([C:8]([N:10]([CH3:12])[CH3:11])=O)[NH:3]1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:14]>N1C=CC=CC=1.O>[O:1]=[C:2]1[NH:6][C:5]([CH3:7])=[C:4]([C:8](=[S:14])[N:10]([CH3:12])[CH3:11])[NH:3]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A suspension of 3.4 g (20 mmol) of 2,3-dihydro--N,N,5-trimethyl-2-oxo-1H-imidazole-4-carboxamide (prepared in example 3) and 4.4 g cf phosphorus pentasulfide in 100 ml of dry pyridine is stirred at reflux temperature for 6 hours. The mixture is allowed to cool overnight and is diluted with water. The precipitate is collected and recrystallized from 50% aqueous ethanol to give the title compound.
Workup
- temperatureat reflux temperature for 6 hours
- temperatureto cool overnight
- customThe precipitate is collected
- customrecrystallized from 50% aqueous ethanol
Sources & evidence
- ORD record
- ord-d4b06bb8ef694eeca746dd9a717b2ddf
- Source dataset
- uspto-grants-1991_03
- Patent number
- US05002961
Reaction notes
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