Chlorine → 1,3-Isobenzofurandione, 5-fluoro-
Reaction equation
[F:1][C:2]1(F)[CH2:12][CH2:11][CH:5]2[C:6]([O:8][C:9](=[O:10])[CH:4]2[CH2:3]1)=[O:7].ClCl>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:10])[O:8][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1Participants
3
Procedure
The procedure of Example III was repeated except that the feed was 4,4-difluorohexahydrophthalic anhydride, the vapor temperature was 240° C., reaction temperature was 255° C., the organic rate was 0.5 grams/minute, and the chlorine rate was 183 ml/min. The product, 4-fluorophthalic anhydride, was produced in 80% yield and 90% purity.
Workup
- customwas 240° C.
- customreaction temperature
- customwas 255° C.
Sources & evidence
- ORD record
- ord-032b60dd621946d4a93f66b106cb3332
- Source dataset
- uspto-grants-1991_03
- Patent number
- US05003088
Reaction notes
Loading…