alpha-Hydroxy-gamma-methylmercaptobutyric acid → 2-Hydroxy-4-(methylsulfanyl)butanamide

HRID 361289

Reaction equation

HRID 361289 reaction equation
[OH:1][CH:2]([CH2:6][CH2:7][S:8][CH3:9])[C:3](O)=[O:4].OC(CCSC)C#[N:13]>>[OH:1][CH:2]([CH2:6][CH2:7][S:8][CH3:9])[C:3]([NH2:13])=[O:4]

Participants

3

Reactant 2

HCID 11427alpha-Hydroxy-gamma-methylmercaptobutyric acidHCID 87302Butanenitrile, 2-hydroxy-4-(methylthio)-2×

Product 1

HCID 103132202-Hydroxy-4-(methylsulfanyl)butanamide

Procedure

A further aspect of the present invention is directed to a process for the preparation of salts of 2-hydroxy-4-(methylthio)-butanoic acid from 2-hydroxy-4-(methylthio)-butanenitrile. 2-Hydroxy-4-(methylthio)-butanenitrile is enzymatically hydrated to form 2-hydroxy-4-(methylthio)-butaneamide, and the resulting 2-hydroxy-4-(methylthio)-butaneamide is hydrolyzed in a basic solution to form a salt of 2-hydroxy-4-(methylthio)-butanoic acid.

Sources & evidence

ORD record
ord-e32ebf6ac3594a0185c017bf9d7a80d3
Source dataset
uspto-grants-1999_02
Patent number
US05866379

Linked notes

Loading…