Nitric Acid → 2,6-Dichloro-5'-nitro-4'-methoxy-2'-methyl-benzophenone

HRID 361971

Reaction equation

[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:7]=1[CH3:14])=[O:5].[N+:20]([O-])([OH:22])=[O:21]>O>[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:3]=1[C:4]([C:6]1[CH:11]=[C:10]([N+:20]([O-:22])=[O:21])[C:9]([O:12][CH3:13])=[CH:8][C:7]=1[CH3:14])=[O:5]

Participants

Conditions

Temperature: 80 °C

Procedure

2,6-Dichloro-4'-methoxy-2'-methyl-benzophenone (0.75 g; 2.5 mmol) is added to nitric acid (10 ml; 65%). The mixture is stirred at 80° C. for 1hour. After addition of water the reaction product crystallises and is chromatographically purified (flash column filled with 30 g of silicagel, elution with toluene). White crystals (0.35 g; 41% y); mp. 156°-160° C.

Workup

customcrystallises
customis chromatographically purified
addition(flash column filled with 30 g of silicagel, elution with toluene)

Sources & evidence

ORD record: ord-7ffdccfbac954e48aa3458fa8a6fa77a
Source dataset: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05866722

Linked notes

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