Diethyl 2-acetylglutarate → HCID 178471086, compound

HRID 362228

Reaction equation

[C:1]([NH2:5])(=[NH:4])[CH2:2][CH3:3].[C:6]([CH:9]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:10](OCC)=[O:11])(=O)[CH3:7]>>[CH2:2]([C:1]1[N:5]=[C:10]([OH:11])[C:9]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:6]([CH3:7])[N:4]=1)[CH3:3]

Participants

Reactant 2

HCID 73915Diethyl 2-acetylglutarate

HCID 415117Propionamidine hydrochloride

Product 1

HCID 178471086HCID 178471086, compoundYield 12,819.8%

Procedure

The title compound (1.99 g) was prepared from 5.00 g of propioamidine and 15.0 mg of diethyl 2-acetylglutarate using the procedure in Example 1, 18% yield.

Sources & evidence

ORD record: ord-c94c35bcd3e247c09b71f29fab56716b
Source dataset: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05869476

Linked notes

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