Ethanol hydrochloride → 1-(1-Naphthyl)-2-((piperazin-2-yl)methoxy]ethanol dihydrochloride
Reaction equation
C([N:3]1[CH2:8][CH2:7][N:6](C=O)[CH2:5][CH:4]1[CH2:11][O:12][CH2:13][CH:14]([C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1)[OH:15])=O.[ClH:26].C(O)C>CO>[ClH:26].[ClH:26].[C:16]1([CH:14]([OH:15])[CH2:13][O:12][CH2:11][CH:4]2[CH2:5][NH:6][CH2:7][CH2:8][NH:3]2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1Participants
4
Procedure
In 1.5 ml of methanol was dissolved 250 mg of 2-[(1,4-diformylpiperazin-2-yl)methoxy]-1-(1-naphthyl)ethanol. To the solution was added 1.5 ml of a 5N dry hydrogen chloride-ethanol solution. The mixture was allowed to stand at room temperature overnight. The resulting crystals were collected by filtration, washed with ethanol, and dried to obtain 180 mg of 1-(1-naphthyl)-2-((piperazin-2-yl)methoxy]ethanol dihydrochloride (compound No. 274).