Sodium Dithionite → 1,3-Di-cyclopropyl-8-amino Xanthine

HRID 3631

Reaction equation

HRID 3631 reaction equation
[CH:1]1([N:4]2[C:13](=[O:14])[C:12]3[NH:11][C:10]([N+:15]([O-])=O)=[N:9][C:8]=3[N:7]([CH:18]3[CH2:20][CH2:19]3)[C:5]2=[O:6])[CH2:3][CH2:2]1.S(S([O-])=O)([O-])=O.[Na+].[Na+]>CO.O>[CH:1]1([N:4]2[C:13](=[O:14])[C:12]3[NH:11][C:10]([NH2:15])=[N:9][C:8]=3[N:7]([CH:18]3[CH2:20][CH2:19]3)[C:5]2=[O:6])[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 24489Sodium DithioniteHCID 98384921,3-Di-cyclopropyl-8-nitro xanthine

Product 1

HCID 98136211,3-Di-cyclopropyl-8-amino Xanthine

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

1,3-Di-cyclopropyl-8-nitro xanthine (0.4 g, 0.0014 mol) was dissolved in methanol (20 ml) and treated with a sodium dithionite solution in water (0.5 g in 5 ml) at room temperature with stirring. After stirring for three hours the solvent was removed in vacuo, the residue taken up with dichloromethane and extracted with water (40 ml).

Workup

  1. stirringAfter stirring for three hours the solvent
  2. customwas removed in vacuo
  3. extractionextracted with water (40 ml)

Sources & evidence

ORD record
ord-6437b784cf604f0ba86ac0d067c33742
Source dataset
uspto-grants-1998_03
Patent number
US05734051

Linked notes

Loading…