Water → 6-Phenylnicotinic acid

HRID 363184

Reaction equation

HRID 363184 reaction equation
[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Mn]([O-])(=O)(=O)=[O:15].[K+].[OH2:20]>>[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]([OH:15])=[O:20])=[CH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 962WaterHCID 474675-Methyl-2-phenylpyridineHCID 516875Potassium Permanganate

Product 1

HCID 1201186-Phenylnicotinic acid

Procedure

A suspension of 2-phenyl-5-methyl pyridine (1.03 g, 6.09 mmol) and potassium permanganate (2.89 g, 18.3 mmol), in water (25 mL) was heated at reflux for 2 hours. The reaction was allowed to cool to ambient temperature and filtered through celite to remove the solids. Acetic acid (1 mL) was added to the colourless filtrate and the product was collected as a white solid by filtration.

Workup

  1. temperatureat reflux for 2 hours
  2. filtrationfiltered through celite
  3. customto remove the solids
  4. additionAcetic acid (1 mL) was added to the colourless filtrate
  5. filtrationthe product was collected as a white solid by filtration

Sources & evidence

ORD record
ord-6e644e5ebedd4852bf22e76bd7adb84c
Source dataset
uspto-grants-1999_02
Patent number
US05872136

Linked notes

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