HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 36340Generated: October 23, 2026
Phosphorus tribromide → 1-(Bromomethyl)-3-chlorobenzene
https://huagongshe.com/en/reaction/36340
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | 3-Chlorobenzyl alcohol | HCID 70117 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(Bromomethyl)-3-chlorobenzene | HCID 69838 | — |
Reaction Steps
A solution of 260 ul of 3-chlorobenzyl alcohol dissolved in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul of PBr3 added. The reaction is stirred for 3 hours and extracted with ether. The organic layer is washed with saturated sodium bicarbonate and evaporated to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05414001 |
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| Source dataset | uspto-grants-1995_05 |
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| ORD ID | ord-2e356bec6541419499a7e4e5503f2522 |
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| Source note | uspto-grants-1995_05 |
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