HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → 3-Methoxybenzyl bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | 3-Methoxybenzyl alcohol | HCID 81437 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Methoxybenzyl bromide | HCID 4067207 | — |
Reaction Steps
A solution of 270 ul of 3-methoxybenzyl alcohol in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul PBr3 added, followed by stirring for three hours. The reaction mixture is extracted with ether and the organic layer washed with saturated sodium bicarbonate and evaporated to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05414001 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-d0021b55fed847d8be332381521d5721 |
| Source note | uspto-grants-1995_05 |