(Aminomethyl)phosphonic acid → Glyphosate

HRID 363809Notes

Reaction equation

HRID 363809 reaction equation
[NH2:1][CH2:2][P:3](=[O:6])([OH:5])[OH:4].O.[C:8]([OH:12])(=[O:11])[CH:9]=O.[H][H]>>[CH2:9]([NH:1][CH2:2][P:3]([OH:5])([OH:4])=[O:6])[C:8]([OH:12])=[O:11]

Participants

4

Reactant 3

HCID 14017(Aminomethyl)phosphonic acidHCID 15620607Glyoxylic acid, monohydrateHCID 178418361HCID 178418361, compound

Product 1

HCID 3496GlyphosateYield 96%

Procedure

Aminomethylphosphonic acid and glyoxylic acid hydrate were reacted under catalytic hydrogenation conditions in the manner described in Example 2, except prior to introduction of hydrogen, the pH was adjusted to 8.0. A 96% yield of glyphosate was obtained.

Sources & evidence

ORD record
ord-aa2d357ff23046789b5dfc6ba8ce96a7
Source dataset
uspto-grants-1999_02
Patent number
US05874612

Reaction notes

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