Butylethanolamine → Ethyl (2-hydroxyethyl)-n-butylcarbamate

HRID 364972Notes

Reaction equation

HRID 364972 reaction equation
[CH2:1]([NH:5][CH2:6][CH2:7][OH:8])[CH2:2][CH2:3][CH3:4].Cl[C:10]([O:12][CH2:13][CH3:14])=[O:11]>C(Cl)Cl>[OH:8][CH2:7][CH2:6][N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[C:10](=[O:11])[O:12][CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 8132ButylethanolamineHCID 10928Ethyl chloroformate

Product 1

HCID 54381911Ethyl (2-hydroxyethyl)-n-butylcarbamate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

117.2 g of 2-(n-butylamino)ethanol and placed in 300 ml of methylene chloride. Then 54.3 g of ethyl chloroformate are allowed to drop in during 1 hour at 30°-35° C. with ice-cooling. After stirring for an additional 2 hours, the methylene chloride is evaporated and the residue is distilled to yield pure ethyl (2-hydroxyethyl)-n-butylcarbamate; b.p. 112° C./0.1 Torr.

Workup

  1. customto drop in during 1 hour at 30°-35° C. with ice-
  2. temperaturecooling
  3. customthe methylene chloride is evaporated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-e4c48b7109eb4425bf1b91aa40ad4609
Source dataset
uspto-grants-1986_08
Patent number
US04607051

Reaction notes

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