HCID 13753169, compound → 4-(3-Fluorophenoxy)phenol

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]C)=[CH:8][CH:7]=1.Br.C(O)(=O)C>>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1

Participants

Reactant 2

HCID 13753169HCID 13753169, compound

HCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Product 1

HCID 109216164-(3-Fluorophenoxy)phenol

Procedure

m-fluorophenol and 4-bromoanisole yield p-(m-fluorophenoxy)anisole of b.p. 130°-131° C./0.2 Torr and reaction with hydrobromic acid/acetic acid yields p-(m-fluorophenoxy)phenol; m.p. 53°-55° C.

Sources & evidence

ORD record: ord-91c6ab9ce6354ecdb3020ec461ca79be
Source dataset: uspto-grants-1986_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04607051

Reaction notes

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