1-(2-Methoxyphenyl)piperazine → 3-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrile

HRID 365295

Reaction equation

HRID 365295 reaction equation
[C:1](#[N:4])[CH:2]=[CH2:3].[CH3:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>C(O)C>[CH3:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:13]1[CH2:18][CH2:17][N:16]([CH2:3][CH2:2][C:1]#[N:4])[CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 7855Acrylonitrile

Product 1

HCID 18226043-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrileYield 91.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of acrylonitrile (1.06 g, 20 mmol) in ethanol (50 ml) was added to a stirred solution of 2-methoxyphenylpiperazine (3.84 g, 20 mmol) in ethanol (100 ml). After 18 h, the solvent was evaporated in vacuo to give the product (4.5 g) as a white solid.

Workup

  1. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-22fea30183c04db69593e05118e5f118
Source dataset
uspto-grants-2000_10
Patent number
US06127357

Linked notes

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