4-Methoxy cinnamic acid → 4-Methoxycinnamic acid chloride
Reaction equation
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9](O)=[O:10])=[CH:5][CH:4]=1.S(Cl)([Cl:16])=O>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]=[CH:8][C:9]([Cl:16])=[O:10])=[CH:5][CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
100 ml of benzene was added to 17.8 grams of p-methoxycinnamic acid. 12 ml of thionyl chloride was added dropwise slowly thereto at ambient temperature. The temperature was elevated to 70° C. and the heating was continued until foaming ceased. Benzene and thionyl chloride were distilled off and the residue was dried thoroughly under reduced pressure.
Workup
- customat ambient temperature
- customwas elevated to 70° C.
- distillationBenzene and thionyl chloride were distilled off
- customthe residue was dried thoroughly under reduced pressure
Sources & evidence
- ORD record
- ord-cd2d68595fc149349eae476c07319826
- Source dataset
- uspto-grants-1995_05
- Patent number
- US05415780
Reaction notes
Loading…