1,3,5-Trichlorobenzene → 1,3,5-Trifluorobenzene

HRID 365965

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([F:9])[CH:8]=1)N.ClC1C=C(Cl)C=C(Cl)C=1.[F-:19]>>[F:1][C:2]1[CH:3]=[C:4]([F:19])[CH:6]=[C:7]([F:9])[CH:8]=1

Participants

Reactant 3

HCID 79501,3,5-Trichlorobenzene2×

HCID 28179Fluoride Ion

HCID 965953,5-Difluoroaniline

Product 1

HCID 97451,3,5-Trifluorobenzene

Procedure

In a further embodiment, the present invention relates to a method for the two step preparation of 3,5-difluoroaniline from 1,3,5-trichlorobenzene. First, an amount of 1,3,5-trichlorobenzene is reacted with a fluoride-containing compound to obtain 1,3,5-trifluorobenzene. Second, the 1,3,5-trifluorobenzene is reacted with aqueous ammonia and a metal oxide or metal hydroxide to obtain the product 3,5-difluoroaniline.

Workup

additioncontaining compound

Sources & evidence

ORD record: ord-45e0cbdb38d34daab543f555c607bb71
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06127577

Linked notes

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