2-Bromobenzyl bromide → 1-Bromo-2-(methoxymethyl)benzene
Reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[CH3:10][O-:11].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:11][CH3:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
685 g (2.74 mol) of o-bromobenzyl bromide was refluxed with 2.74 mol of a 30% strength sodium methylate solution in methanol for 15 hours. After the mixture had cooled to room temperature it was evaporated down, taken up in ethyl acetate, and washed with water. After the organic phase had been dried over sodium sulfate, it was again evaporated down. There was obtained 478.2 g (87%) of the title substance as a colorless liquid.
Workup
- customwas evaporated down
- washwashed with water
- dry with materialAfter the organic phase had been dried over sodium sulfate, it
- customwas again evaporated down
- customThere was obtained 478.2 g (87%) of the title substance as a colorless liquid
Sources & evidence
- ORD record
- ord-38dfa61d18674d36a2a17eda1d4b5eb3
- Source dataset
- uspto-grants-1995_05
- Patent number
- US05416068
Reaction notes
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