Benzylamine → 2-Chloro-6-methyl-4-benzylamino-thieno-[2,3-d]-pyrimidine

Reaction equation

[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:9][C:10]1[N:11]=[C:12](Cl)[C:13]2[CH:18]=[C:17]([CH3:19])[S:16][C:14]=2[N:15]=1>>[Cl:9][C:10]1[N:11]=[C:12]([NH:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:13]2[CH:18]=[C:17]([CH3:19])[S:16][C:14]=2[N:15]=1

Participants

Reactant 2

HCID 7504Benzylamine

HCID 111068472,4-Dichloro-6-methylthieno[2,3-D]pyrimidine

Product 1

HCID 184601702-Chloro-6-methyl-4-benzylamino-thieno-[2,3-d]-pyrimidine

Procedure

Following the procedure of Example 1, the reaction of benzylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-benzylamino-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record: ord-df090bb8258d451c87206cda1758b81e
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133271

Reaction notes

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