Benzylamine → 2,5-Dichloro-6-methyl-4-benzylamino-thieno-[2,3-d]-pyrimidine

Reaction equation

[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:9][C:10]1[N:11]=[C:12](Cl)[C:13]2[C:18]([Cl:19])=[C:17]([CH3:20])[S:16][C:14]=2[N:15]=1>>[Cl:9][C:10]1[N:11]=[C:12]([NH:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:13]2[C:18]([Cl:19])=[C:17]([CH3:20])[S:16][C:14]=2[N:15]=1

Participants

Reactant 2

HCID 7504Benzylamine

HCID 127242442,4,5-Trichloro-6-methyl-thieno-[2,3-d]-pyrimidine

Product 1

HCID 184604702,5-Dichloro-6-methyl-4-benzylamino-thieno-[2,3-d]-pyrimidine

Procedure

Following the procedure of Example 1, the reaction of benzylamine with 2,4,5-trichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2,5-dichloro-6-methyl-4-benzylamino-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record: ord-91ef2e0f7da143418cc8f0e6f1746c1a
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133271

Reaction notes

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