4-Fluorobenzylamine → 2,5-Dichloro-6-methyl-4-(4-fluorobenzylamino)-thieno-[2,3-d]-pyrimidine

Reaction equation

[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.[Cl:10][C:11]1[N:12]=[C:13](Cl)[C:14]2[C:19]([Cl:20])=[C:18]([CH3:21])[S:17][C:15]=2[N:16]=1>>[Cl:10][C:11]1[N:12]=[C:13]([NH:7][CH2:6][C:5]2[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=2)[C:14]2[C:19]([Cl:20])=[C:18]([CH3:21])[S:17][C:15]=2[N:16]=1

Participants

Reactant 2

HCID 673264-Fluorobenzylamine

HCID 127242442,4,5-Trichloro-6-methyl-thieno-[2,3-d]-pyrimidine

Product 1

HCID 184602422,5-Dichloro-6-methyl-4-(4-fluorobenzylamino)-thieno-[2,3-d]-pyrimidine

Procedure

Following the procedure of Example 1, the reaction of 4-fluorobenzylamine with 2,4,5-trichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2,5-dichloro-6-methyl-4-(4-fluorobenzylamino)-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record: ord-91a7f728afba482ea9f3fb34a0f96d70
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133271

Reaction notes

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