N-(2-Hydroxyethyl)imidazole → 7-[2-(1H-Imidazolyl)ethoxy]-2,2-dimethyl-4-chromanone

HRID 368355

Reaction equation

HRID 368355 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:14])[CH2:7][C:8]([CH3:13])([CH3:12])[O:9]2)=[CH:4][CH:3]=1.O[CH2:16][CH2:17][N:18]1[CH:22]=[CH:21][N:20]=[CH:19]1>>[N:18]1([CH2:17][CH2:16][O:1][C:2]2[CH:11]=[C:10]3[C:5]([C:6](=[O:14])[CH2:7][C:8]([CH3:12])([CH3:13])[O:9]3)=[CH:4][CH:3]=2)[CH:22]=[CH:21][N:20]=[CH:19]1

Participants

3

Reactant 2

HCID 74168N-(2-Hydroxyethyl)imidazoleHCID 6009027-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-one

Product 1

HCID 186265237-[2-(1H-Imidazolyl)ethoxy]-2,2-dimethyl-4-chromanone

Procedure

Following the procedure of Example 30 but using 7-hydroxy-2,2-dimethyl-4-chromanone and 1-(2-hydroxyethyl)imidazole, there was obtained the title compound as a solid, mp 84-86° C. The structure was confirmed by NMR and mass spectroscopy. MS m/z 287 (M+H+).

Sources & evidence

ORD record
ord-a92fc503c73043c686e1c39952bfb854
Source dataset
uspto-grants-2000_10
Patent number
US06133303

Linked notes

Loading…