Methanol → 3,5,6-Trifluoropyridin-2-amine
Reaction equation
CO.C([NH:10][C:11]1[C:16]([F:17])=[CH:15][C:14]([F:18])=[C:13]([F:19])[N:12]=1)C1C=CC=CC=1>[Pd].C(O)(=O)C>[NH2:10][C:11]1[C:16]([F:17])=[CH:15][C:14]([F:18])=[C:13]([F:19])[N:12]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To 40 ml of methanol were added 7.60 g of the crude 2-benzylamino-3,5,6-trifluoropyridine as described above together with 0.55 g of 10% palladium on carbon and 2 ml acetic acid, and the mixture was hydrogenated at 50° C. for one day. The catalyst was separated by filtration, and the solvent and the like were distilled off under reduced pressure. The precipitate was dispersed in n-hexane, and collected by filtration to obtain 3.85 g of the title compound as a colorless solid.
Workup
- customThe catalyst was separated by filtration
- distillationthe solvent and the like were distilled off under reduced pressure
- additionThe precipitate was dispersed in n-hexane
- filtrationcollected by filtration
Sources & evidence
- ORD record
- ord-a71a07fba67a43aca1637d0690172013
- Source dataset
- uspto-grants-2000_10
- Patent number
- US06133284
Reaction notes
Loading…