Methyl iodide → HCID 18630005, compound

Reaction equation

[CH2:1]([N:3]([CH2:16][O:17][CH3:18])[C:4](=[O:15])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Si:11]([CH3:14])([CH3:13])[CH3:12])[CH3:2].[CH3:19]I>>[CH2:1]([N:3]([CH2:16][O:17][CH3:18])[C:4](=[O:15])[C:5]1[C:6]([Si:11]([CH3:13])([CH3:12])[CH3:14])=[CH:7][CH:8]=[CH:9][C:10]=1[CH3:19])[CH3:2]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 18630303HCID 18630303, compound

Product 1

HCID 18630005HCID 18630005, compound

Procedure

The compound of Example 50 (1.33 g, 5.0 mmol) and MeI (2.8 g, 20 mmol) were combined according to General Method B. The resulting reaction was partitioned between ethyl acetate and sat aq NaHCO3. The organic phase was washed with brine, dried (MgSO4), and concentrated to afford a quantitative yield of the title compound as an oil.

Workup

customThe resulting reaction
customwas partitioned between ethyl acetate
washThe organic phase was washed with brine
dry with materialdried (MgSO4)
concentrationconcentrated

Sources & evidence

ORD record: ord-0d1400b3fa674b63a339220629478a68
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133252

Reaction notes

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