4-Fluorobenzenesulfonamide → (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]-cis-3,5-dimethylpiperazin-1-yl]benzenesulfonamide

Reaction equation

[CH3:1][CH:2]1[NH:7][CH:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:14]=[CH:13][C:12]([S:15]([NH2:18])(=[O:17])=[O:16])=[CH:11][CH:10]=2)[CH2:3]1.N1(C2C=CC(S(N)(=O)=O)=CC=2)CCNCC1.FC1C=CC(S(N)(=O)=O)=CC=1.Cl[CH2:47][CH2:48][CH:49]1[C:58]2[C:53](=[CH:54][CH:55]=[CH:56][CH:57]=2)[CH:52](C)[CH2:51][O:50]1.C[C@H]1CNC[C@@H](C)N1.C1(C[C@H]2COC(=O)N2C(=O)C(C2C=CC=CC=2)C)C=CC=CC=1>>[C@H:49]1([CH2:48][CH2:47][N:7]2[C@@H:6]([CH3:8])[CH2:5][N:4]([C:9]3[CH:10]=[CH:11][C:12]([S:15]([NH2:18])(=[O:16])=[O:17])=[CH:13][CH:14]=3)[CH2:3][C@H:2]2[CH3:1])[C:58]2[C:53](=[CH:54][CH:55]=[CH:56][CH:57]=2)[CH2:52][CH2:51][O:50]1