4-(Piperazin-1-yl)benzene-1-sulfonamide → 4-[4-((R)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide

HRID 368872

Reaction equation

HRID 368872 reaction equation
[CH:1]1([CH2:11][CH2:12]O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][O:2]1.[N:14]1([C:20]2[CH:25]=[CH:24][C:23]([S:26]([NH2:29])(=[O:28])=[O:27])=[CH:22][CH:21]=2)[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[C@@H:1]1([CH2:11][CH2:12][N:17]2[CH2:18][CH2:19][N:14]([C:20]3[CH:25]=[CH:24][C:23]([S:26]([NH2:29])(=[O:28])=[O:27])=[CH:22][CH:21]=3)[CH2:15][CH2:16]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][O:2]1

Participants

3

Reactant 2

HCID 9018974-(Piperazin-1-yl)benzene-1-sulfonamideHCID 14141298(-)-2-(Isochroman-1-yl)ethanol

Product 1

HCID 108110594-[4-((R)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide

Procedure

Following the general procedure of EXAMPLE 49 and making non-critical variations 2-(isochroman-1-yl)ethanol (LXXIX, (+)-enantiomer, 0.6045 g) and 4-(piperazin-1-yl)benzenesulfonamide (IV, 0.9824 g) are combined to give the title compound, mp 189-190°; MS (m/z) 401; [α]D +48 (c 0.877, DMF); IR (mineral oil) 1662, 1594, 1150, 1101, 614 cm-1.

Sources & evidence

ORD record
ord-67c5e8aca1214ce6ae6cd55953054aed
Source dataset
uspto-grants-2000_10
Patent number
US06133446

Linked notes

Loading…