Potassium Nitrate → 1-Bromo-4-fluoro-5-methyl-2-nitrobenzene
Reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:9])=[C:6]([CH3:8])[CH:7]=1.[N+:10]([O-])([O-:12])=[O:11].[K+]>S(=O)(=O)(O)O>[Br:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[CH:4][C:5]([F:9])=[C:6]([CH3:8])[CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
5-Bromo-2-fluorotoluene (7.65 g) was added to concentrated sulfuric acid (40 ml), and potassium nitrate (4.2 g) was added portionwise to the mixture at -20° C. The temperature of the reaction mixture was given back to room temperature to conduct stirring for 3 days, and then poured into ice water to conduct extraction with ethyl acetate. After an organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off to obtain the title compound (9.9 g) as a pale yellow oil.
Workup
- additionwas added portionwise to the mixture at -20° C
- customwas given back to room temperature
- extractionextraction with ethyl acetate
- dry with materialAfter an organic layer was dried over anhydrous magnesium sulfate
- distillationthe solvent was distilled off
Sources & evidence
- ORD record
- ord-6f2bc81ea0144785a0dd9ea6908bf2aa
- Source dataset
- uspto-grants-2000_10
- Patent number
- US06136823
Reaction notes
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