HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydroquinoline → 4-(1,2,3,4-Tetrahydroquinolin-1-yl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| Reactant | 4-chloro-5,6-dimethyl-7H-pyrrolo(2,3-d)pyrimidine | HCID 13041144 | — |
| Solvent | Toluene acetone | HCID 20247278 | — |
| Product | 4-(1,2,3,4-Tetrahydroquinolin-1-yl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine | HCID 23282462 | — |
Reaction Steps
This product is prepared in a manner analogous to that described in Example 1 from 4-chloro-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine and 1,2,3,4-tetrahydroquinoline (4 equivalents, Fluka, Buchs, Switzerland). M.p: 263-264° C.; FAB-MS: (M+H)+ =279 (corresponds to C17H18N4); Rf value (toluene-acetone--(4:6))=0.29.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06140317 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-76ac5485e1334e7499be9b28474d231e |
| Source note | uspto-grants-2000_10 |