4-(6-Chloro-2,3-dihydroindol-1-yl)-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine → 4-(6-Chloro-2,3-dihydroindol-1-yl)-6-(4-amino-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine
Reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:11]2[C:12]3[CH:19]=[C:18]([C:20]4[CH:25]=[CH:24][C:23]([N+:26]([O-])=O)=[CH:22][CH:21]=4)[NH:17][C:13]=3[N:14]=[CH:15][N:16]=2)=[CH:4][CH:3]=1>[Ni]>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:11]2[C:12]3[CH:19]=[C:18]([C:20]4[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][CH:21]=4)[NH:17][C:13]=3[N:14]=[CH:15][N:16]=2)=[CH:4][CH:3]=1Participants
3
Procedure
This product is obtained in a manner analogous to that described in Example 7 by hydrogenation of 4-(6-chloro-2,3-dihydroindol-1-yl)-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine (Example 8) with Raney nickel.
Workup
- customThis product is obtained in a manner analogous to