HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 36977Generated: October 24, 2026
Acetic Anhydride → (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)-2-propenoic acid
https://huagongshe.com/en/reaction/36977
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Thiopheneacetic acid | HCID 15970 | — |
| Reactant | 1H-Imidazole-5-carboxaldehyde, 2-butyl-1-[(2-chlorophenyl)methyl]- | HCID 10107530 | — |
| Solvent | Water | HCID 962 | — |
| Product | (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)-2-propenoic acid | HCID 69948967 | — |
Reaction Steps
A mixture of 2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-carboxaldehyde (2 mmol), 2-thienylacetic acid (2.3 mmol), potassium carbonate (0.91 mmol), and acetic anhydride (1 mL) is heated gradually to 140° C. and held at this temperature for 6 hours. The cooled reaction is diluted with water and the solid is separated, triturated several times with ether, and the solid is crystallized to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05418250 |
|---|
| Source dataset | uspto-grants-1995_05 |
|---|
| ORD ID | ord-9f5c38a8d3ec4df8a69471349893b3ad |
|---|
| Source note | uspto-grants-1995_05 |
|---|
