Hexanoate → 2-(3'-Chlorophenyl)-5,5-dimethyl-1,3-cyclohexanedione

HRID 370386

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:8](C#N)[C:9](=[O:20])[CH2:10][C:11]([CH3:19])([CH3:18])[CH2:12][C:13]([O:15]CC)=O)[CH:5]=[CH:6][CH:7]=1.C([O-])(=O)CCCCC>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:9](=[O:20])[CH2:10][C:11]([CH3:18])([CH3:19])[CH2:12][C:13]2=[O:15])[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 4398339Hexanoate

HCID 20275820Ethyl 6-(3'chlorophenyl)-6-cyano-5-keto-3,3-dimethylhexanoate

Product 1

HCID 132597722-(3'-Chlorophenyl)-5,5-dimethyl-1,3-cyclohexanedione

Procedure

This dione was prepared by the acid cyclization of ethyl 6-(3'chlorophenyl)-6-cyano-5-keto-3,3-dimethylhexanoate. Preparation of the hexanoate is described in Part A and of the dione in Part B below.

Sources & evidence

ORD record: ord-dae522f735ba49fbb213c222fedb8f48
Source dataset: uspto-grants-1985_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04526723

Linked notes

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