HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 9-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl)adenine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 2'-Fluoro-2'-deoxyadenosine | HCID 100253 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 9-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl)adenine hydrochloride | HCID 67740756 | — |
Reaction Steps
To a solution of 9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)adenine (500 mg. 1.86 mmol) in MeOH (40 ml) and water (10 ml) was added a solution of isopropanol (15 ml) previously saturated with HCl gas. The solution was evaporated under vacuum at room temperature, and triturated with EtOH (25 ml) to afford the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05420115 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-6f3bdcf96f5c441380f7fe1672130045 |
| Source note | uspto-grants-1995_05 |