Acetic Acid → HCID 178516129, compound

HRID 37134

Reaction equation

HRID 37134 reaction equation
C(O)(=O)C.[NH2:5][C:6]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([S:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:13][CH:12]=2)=[CH:9][NH:8][N:7]=1.[F:24][C:25]([F:35])([F:34])[C:26](=O)[CH2:27][C:28](OCC)=[O:29]>CCOCC>[OH:29][C:28]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:12]=[CH:13][C:14]([S:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:15][CH:16]=3)=[C:6]2[N:5]=[C:26]([C:25]([F:35])([F:34])[F:24])[CH:27]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 67793Ethyl 4,4,4-trifluoroacetoacetateHCID 178509258HCID 178509258, compound

Product 1

HCID 178516129HCID 178516129, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
100 °C

Procedure

In an 8 ml acetic acid solution of 1.07 g of 3-amino-4-(4phenylthiophenyl)pyrazole, 0.6 ml of ethyl 4,4,4-trifluoroacetoacetate was added and stirred for 2 hours at 100° C. After allowing to cool, ether was added, and the precipitate was filtered and dried, and the title compound was obtained (200 mg, 13%).

Workup

  1. temperatureto cool
  2. filtrationthe precipitate was filtered
  3. customdried

Sources & evidence

ORD record
ord-7764346d11f4457dbeff3dc3fdad1d99
Source dataset
uspto-grants-1995_05
Patent number
US05420128

Linked notes

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