1-(Bis(4-fluorophenyl)methyl)piperazine → 7-Hydroxy-6-tert-butyl-2-{4-[bis-(4-fluorophenyl) methyl]piperazin-1-ylcarbonyl}-I,4-benzodioxin

HRID 37169

Reaction equation

HRID 37169 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[OH:22][C:23]1[C:24]([C:36]([CH3:39])([CH3:38])[CH3:37])=[CH:25][C:26]2[O:31][CH:30]=[C:29]([C:32](O)=[O:33])[O:28][C:27]=2[CH:35]=1>>[OH:22][C:23]1[C:24]([C:36]([CH3:39])([CH3:38])[CH3:37])=[CH:25][C:26]2[O:31][CH:30]=[C:29]([C:32]([N:12]3[CH2:11][CH2:10][N:9]([CH:8]([C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=4)[C:15]4[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=4)[CH2:14][CH2:13]3)=[O:33])[O:28][C:27]=2[CH:35]=1

Participants

3

Reactant 2

HCID 1529321-(Bis(4-fluorophenyl)methyl)piperazineHCID 193925057-Hydroxy-6-tert-butyl-1,4-benzodioxin-2-carboxylic acid

Product 1

HCID 193924827-Hydroxy-6-tert-butyl-2-{4-[bis-(4-fluorophenyl) methyl]piperazin-1-ylcarbonyl}-I,4-benzodioxinYield 72%

Procedure

That compound is obtained in a yield of 72% starting from 1-[bis(4-fluorophenyl)methyl]piperazine and 7-hydroxy-6-tert-butyl-1,4-benzodioxin-2-carboxylic acid.

Workup

  1. customThat compound is obtained in a yield of 72%

Sources & evidence

ORD record
ord-c969d6e199bb41dda9ce0475ef999fb6
Source dataset
uspto-grants-1995_05
Patent number
US05420132

Linked notes

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