Cyclohexylamine → HCID 18756975, compound

HRID 371699

Reaction equation

HRID 371699 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:8]([CH2:11][P:12](=[O:17])([O:15]C)[O:13]C)(O)=[O:9].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[CH:1]1([NH:7][C:8]([CH2:11][P:12](=[O:13])([OH:17])[OH:15])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 7965CyclohexylamineHCID 10868DicyclohexylcarbodiimideHCID 1899642-(Dimethoxyphosphoryl)acetic acid

Product 1

HCID 18756975HCID 18756975, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Cyclohexyl amine (0.045 mole) and dimethyl (carboxymethyl)phosphonate (0.04 mole) were dissolved in 100 ml. of methylene chloride. As the solution was stirred, dicyclohexylcarbodiimide (0.045 mole) was added portionwise. The solution was stirred overnight and the mixture filtered. The filtrate was concentrated to a solid and the solid recrystallized from an appropriate solvent such as methanol. m.p. 180°-3° C.; yield 57%.

Workup

  1. stirringThe solution was stirred overnight
  2. filtrationthe mixture filtered
  3. concentrationThe filtrate was concentrated to a solid
  4. customthe solid recrystallized from an appropriate solvent such as methanol

Sources & evidence

ORD record
ord-fa57d76245684623a517de4b633bf7ab
Source dataset
uspto-grants-1978_05
Patent number
US04087522

Linked notes

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