Sodium Hydroxide → 2-(1-Methyl-4-imidazolyl)ethylguanidine sulphate

HRID 372010

Reaction equation

HRID 372010 reaction equation
[S:1]([O-:5])([O-:4])(=[O:3])=[O:2].CS[C:8]([NH2:10])=[NH2+:9].CSC(N)=[NH2+].Cl.Cl.[CH3:18][N:19]1[CH:23]=[C:22]([CH2:24][CH2:25][NH2:26])[N:21]=[CH:20]1.[OH-].[Na+]>O>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[CH3:18][N:19]1[CH:23]=[C:22]([CH2:24][CH2:25][NH:26][C:8]([NH2:10])=[NH:9])[N:21]=[CH:20]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 6604939S-methyl isothiourea hemisulfateHCID 119576011-Methylhistamine dihydrochloride

Product 1

HCID 1784812702-(1-Methyl-4-imidazolyl)ethylguanidine sulphate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

An aqueous solution of S-methylthiouronium sulphate (2.1 g) is added to a solution prepared from 1-methyl-4-(2-aminoethyl)imidazole dihydrochloride (3.0 g) and sodium hydroxide (1.21 g) in water. The resultant solution is heated under reflux for 17 hours. The product, isolated in a manner similar to that described in Example 1 is recrystallized from aqueous ethanol yielding pure 2-(1-methyl-4-imidazolyl)ethylguanidine sulphate, m.p. 280°-282° C.

Workup

  1. temperatureunder reflux for 17 hours
  2. customThe product, isolated in a manner similar to
  3. customis recrystallized from aqueous ethanol yielding pure 2-(1-methyl-4-imidazolyl)ethylguanidine sulphate, m.p. 280°-282° C.

Sources & evidence

ORD record
ord-ab8156ea395f48b1abfaeb368f94d37e
Source dataset
uspto-grants-1978_05
Patent number
US04088769

Linked notes

Loading…