3-(Pyridin-2-yl)propan-1-amine → HCID 178512789, compound

HRID 372012

Reaction equation

HRID 372012 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1.[S:11]([O-:15])([O-:14])(=[O:13])=[O:12].CS[C:18]([NH2:20])=[NH2+:19].CSC(N)=[NH2+]>O>[S:11]([OH:15])([OH:14])(=[O:13])=[O:12].[N:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[CH2:4][CH2:3][CH2:2][NH:1][C:18]([NH2:20])=[NH:19]

Participants

4

Reactant 2

HCID 31596143-(Pyridin-2-yl)propan-1-amineHCID 6604939S-methyl isothiourea hemisulfate

Product 1

HCID 178512789HCID 178512789, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2-(3-aminopropyl)pyridine (2.72 g) and S-methylthiouronium sulphate (2.78 g) in water (40 ml) is heated under reflux for 28 hours. The product isolated by the manner described in Example 1 was recrystallized from methanol, yielding 3-(2-pyridyl)propylguanidine sulphate, m.p. 185°-187° C.

Workup

  1. temperatureunder reflux for 28 hours
  2. customThe product isolated by the manner
  3. customwas recrystallized from methanol

Sources & evidence

ORD record
ord-7f50331ed03b4f5c90002a3e7ae7bccd
Source dataset
uspto-grants-1978_05
Patent number
US04088769

Linked notes

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