4,N,N-Trimethylbenzamide → isopropyl 5-p-toluoyl-1,2-dihydro-6-methyl-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[CH:8]([C:9]([O:11][CH:12]([CH3:14])[CH3:13])=[O:10])[CH2:7][CH2:6][N:5]2[CH:15]=1.CN(C)[C:18]([C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)=[O:19]>>[CH:12]([O:11][C:9]([CH:8]1[CH2:7][CH2:6][N:5]2[C:15]([C:18]([C:20]3[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=3)=[O:19])=[C:2]([CH3:1])[CH:3]=[C:4]12)=[O:10])([CH3:13])[CH3:14]Participants
3
Procedure
In accordance with the method of Example 8, isopropyl 1,2-dihydro-6-methyl-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate is condensed with N,N-dimethyl-p-toluamide, to produce isopropyl-5-p-toluoyl-1,2-dihydro-6-methyl-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate (XI, R = CH3, R1 = p-CH3, R2 = iC3H7).
Sources & evidence
- ORD record
- ord-77d3fde4932c4133b34d4240e81c3161
- Source dataset
- uspto-grants-1978_05