Thionyl Chloride → HCID 20326456, compound
Reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:8][C:9](=[O:16])[C:10](=[CH:14][CH:15]=2)[C:11](O)=O)=[CH:3][CH:2]=1.S(Cl)([Cl:19])=O>CCCCCC>[ClH:19].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:8][C:9](=[O:16])[C:10](=[CH:14][CH:15]=2)[CH2:11][Cl:19])=[CH:3][CH:2]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 13 g. of 6-(4-pyridyl)-1,2-dihydro-2-oxonicotinic acid (U.S. Pat. No. 3,873,523) and 90 ml. of thionyl chloride is stirred at room temperature for 16 hours, then diluted with 250 ml. of hexane. The resulting precipitate of 6-(4-pyridyl)-1,2-dihydro-2-oxonicotinyl chloride hydrochloride is collected by filtration, washed with hexane and dried.
Workup
- additionA mixture of 13 g
- additiondiluted with 250 ml
- filtrationThe resulting precipitate of 6-(4-pyridyl)-1,2-dihydro-2-oxonicotinyl chloride hydrochloride is collected by filtration
- washwashed with hexane
- customdried
Sources & evidence
- ORD record
- ord-9e901e3f04f341e989b448ffc6cd75c1
- Source dataset
- uspto-grants-1978_05
- Patent number
- US04092309
Reaction notes
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