Sodium Methoxide → 2-Methoxy-5-phenylsulfinylpyridine
Reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:4][N:3]=1.[CH3:16][O-:17].[Na+]>CO>[CH3:16][O:17][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:4][N:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2-bromo-5-phenylsulfinylpyridine (2.82 g., 0.01 mole) and 0.50 g. of sodium methoxide is heated in 50 ml. of refluxing methanol for 5 hours. The reaction mixture is evaporated in vacuo, and the residue is diluted with water. The solids are collected by filtration, washed with water and dried to yield 2-methoxy-5-phenylsulfinylpyridine.
Workup
- customThe reaction mixture is evaporated in vacuo
- additionthe residue is diluted with water
- filtrationThe solids are collected by filtration
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-08450c8075fc4dc7bf677910a004504e
- Source dataset
- uspto-grants-1978_05
- Patent number
- US04092321
Reaction notes
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