Phosphonoacetic Acid → Methylacetylphosphonate

Reaction equation

[P:1]([CH2:5][C:6]([OH:8])=[O:7])([OH:4])([OH:3])=[O:2].[CH3:9]O>>[P:1]([CH2:5][C:6]([O:8][CH3:9])=[O:7])([OH:4])([OH:3])=[O:2]

Participants

Reactant 2

HCID 546Phosphonoacetic Acid

HCID 887Methanol

Product 1

HCID 170449Methylacetylphosphonate

Procedure

Phosphonoacetic acid, 5 g., was dissolved in 25 ml. methyl alcohol. Dry hydrogen chloride was bubbled through the solution for 30 minutes at O° C. The solution was refluxed for 4 hours. Evaporation of the solvent left an oil which was dried in vacuo over P2O5 and NaOH.

Workup

dissolution, was dissolved in 25 ml
customDry hydrogen chloride was bubbled through the solution for 30 minutes at O° C
temperatureThe solution was refluxed for 4 hours
customEvaporation of the solvent
waitleft an oil which
dry with materialwas dried in vacuo over P2O5 and NaOH

Sources & evidence

ORD record: ord-e713fe8e17ed41778c36d3a33e7ed9e7
Source dataset: uspto-grants-1978_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04092412

Reaction notes

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