HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acrylate → Ethyl 3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acrylate | HCID 8821 | — |
| Reactant | 4-Chlorobenzylpiperazine | HCID 134826 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propionate | HCID 20326894 | 92.8% |
Reaction Steps
Analogously to Example 1a, 30 g (0.3 mol) ethyl acrylate and 63.2 g 1-(4-chlorobenzyl)-piperazine are reacted in 200 ml ethanol to give 86.5 g (92.8% of theory) ethyl 3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propionate; b.p. 150° - 160° C./0.1 mm Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04092416 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-323212d42a5a467087745b51dab23c98 |
| Source note | uspto-grants-1978_05 |