Pyridine, 3-(2-chloroethyl)-, hydrochloride → 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(4-methylsulfonylaminophenylthio)piperidine

HRID 373146

Reaction equation

HRID 373146 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12][CH:13]2[CH2:18][CH2:17][N:16](CCC3C=NC=CC=3)[CH2:15][CH2:14]2)=[CH:8][CH:7]=1)(=[O:4])=[O:3].Cl.N1C=CC=C(CCCl)C=1.[CH3:37][O:38][C:39]1[CH:40]=[C:41]([CH:45]=[CH:46][C:47]=1[O:48][CH3:49])[CH2:42][CH2:43]Cl>>[CH3:37][O:38][C:39]1[CH:40]=[C:41]([CH2:42][CH2:43][N:16]2[CH2:17][CH2:18][CH:13]([S:12][C:9]3[CH:8]=[CH:7][C:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:11][CH:10]=3)[CH2:14][CH2:15]2)[CH:45]=[CH:46][C:47]=1[O:48][CH3:49]

Participants

4

Reactant 3

HCID 199465Pyridine, 3-(2-chloroethyl)-, hydrochlorideHCID 30153594-(2-Chloroethyl)-1,2-dimethoxybenzeneHCID 156154214-(4-Methylsulfonylaminophenylthio)-1-[2-(3-pyridyl)ethyl]piperidine

Product 1

HCID 156154221-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(4-methylsulfonylaminophenylthio)piperidine

Procedure

The same procedure as that of Example 1 (1) to (8) was repeated except that 2-(3-pyridyl)ethyl chloride hydrochloride was replaced with 3,4-dimethoxyphenethyl chloride to prepare the intended compound.

Workup

  1. customto prepare the intended compound

Sources & evidence

ORD record
ord-49220890dab244dc80857fcfbe992d4a
Source dataset
uspto-grants-1992_11
Patent number
US05162347

Linked notes

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