Cytidine → 4-amino-1-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

HRID 37348

Reaction equation

HRID 37348 reaction equation
[C@@H:1]1([N:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12][C:11]2=[O:17])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@H:2]1[OH:3].[OH-].[K+]>CO>[C@H:1]1([N:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12][C:11]2=[O:17])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@H:2]1[OH:3]

Participants

4

Reactant 2

HCID 6175CytidineHCID 14797Potassium Hydroxide

Product 1

HCID 12659014-amino-1-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The process of claim 27 wherein 1-(β-D-ribofuranosyl)-4-aminopyrimidin-2-one is contacted with potassium hydroxide in methanol to form 1-(α-D-ribofuranosyl)-4-aminopyrimidin-2-one

Sources & evidence

ORD record
ord-12b6769bb04b422a8e38d1043b6f9c35
Source dataset
uspto-grants-1995_05
Patent number
US05420266

Linked notes

Loading…