2-Methoxyethanol → Bis(2-methoxyethyl) carbonate

Temperature

102 °C

A total of 76.1 grams (1 mole) of 2-methoxyethanol, 67.6 grams (0.75 moles) of dimethyl carbonate, and 0.5 grams of dibutyltin dimethoxide were combined in a 250 milliliter round bottom three-neck flask equipped with a straight distillation head and a magnetic stirrer. The flask contents were heated to reflux at an initial temperature of 73° C. at the head and 102° C. in the kettle. After seven minutes at reflux, a methanol/dimethyl carbonate azeotrope was slowly removed overhead. A total of 55.9 grams of material was removed overhead (64° C.-88° C.) over a period of about 21 hours after which time the kettle temperature rose to 145° C. After this time, the flask contents were cooled and put under vacuum. The desired product was collected at a temperature of 97° C.-105° C. at 3 mm Hg. A total of 77.98 grams (87.5 percent yield) of bis(2-methoxyethyl)carbonate was obtained at a purity of greater than 99 percent as analyzed by capillary gas chromatography on a DB-1701 column.

1. customequipped with a straight distillation head and a magnetic stirrer
2. temperatureThe flask contents were heated
3. temperatureAfter seven minutes at reflux
4. customA total of 55.9 grams of material was removed overhead (64° C.-88° C.) over a period of about 21 hours after which time the kettle temperature
5. customrose to 145° C
6. temperatureAfter this time, the flask contents were cooled
7. customThe desired product was collected at a temperature of 97° C.-105° C. at 3 mm Hg

ORD record

ord-4f5f93dba98142028c5a5bbe2ca04f4e

Source dataset

uspto-grants-1992_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05164497